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During the late 1980s we showed that ca 2 stores can be mobilized by two other messengers unrelated to inositol trisphosphate ip 3 and identified them as cyclic adp ribose cadpr a novel cyclic nucleotide from nad and nicotinic acid adenine dinucleotide phosphate naadp a linear metabolite of nadp their messenger functions have now . Cyclic adp ribose frequently abbreviated as cadpr is a cyclic adenine nucleotide like camp with two phosphate groups present on 5 oh of the adenosine like adp further connected to another ribose at the 5 position which in turn closes the cycle by glycosidic bonding to the nitrogen 1 n 1 of the same adenine base whose position n 9 has the glycosidic bond to the other ribose. Hon cheung lee cyclic adp ribose and naadp structures metabolism and functions pdf ebook in english with adobe drm in the past decade we have witnessed the birth and maturing of a field of research centering on the ca2 signaling functions of cyclic adp ribose c adpr and nicotinic acid adenine dinucleotide . Hon cheung lee eur as messengers for calcium mobilization adenine dinucleotide phosphate naadp cyclic adp ribose and nicotinic acid minireviews doi 101074 jbcr112349464 originally published online july 20 2012 j biol chemeur2012 28731633 31640 eur. Cyclic adp ribose and naadp structures metabolism and functions editor hon cheung lee minneapolis usa cover designs front the space filling model on the left is that of cadpr and is based on x ray crystallography the molecule on the right is naadp